This research guide is adapted from GATEWAY COMMUNITY COLLEGE LIBRARY (GWC) Special thanks to former colleagues there!
Evidence-Based Medicine is the integration of best research evidence with clinical expertise and patient values. (Sackett DL, Straus SE, Richardson WS, et al. Evidence-based medicine: how to practice and teach EBM. 2nd ed. Edinburgh: Churchill Livingstone, 2000.)
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TRIP (Turning Research Into Practice) Database Plus
Simultaneously searches evidence-based sources of systematic reviews, practice guidelines, and critically-appraised topics and articles -- including most of those listed above and many more. Also searches MEDLINE’s Clinical Queries, medical image databases, e-textbooks, and patient information leaflets.
Filtered resources appraise the quality of studies and often make recommendations for practice.
Systematic Reviews / Meta-Analyses
Authors of a systematic review ask a specific clinical question, perform a comprehensive literature search, eliminate the poorly done studies and attempt to make practice recommendations based on the well-done studies. A meta-analysis is a systematic review that combines all the results of all the studies into a single statistical analysis of results.
The Cochrane Database of Systematic Reviews
Consists of detailed, structured topic reviews of hundreds of articles. Teams of experts complete comprehensive literature reviews, evaluate the literature, and present summaries of the findings of the best studies. Published by the International Cochrane Collaboration.
Via EBSCO
The Database of Abstracts of Reviews of Effect (DARE)
Full-text database containing structured abstracts of systematic reviews from a variety of medical journals. DARE is produced by the National Health Services' Centre for Reviews and Dissemination (NHS CRD) at the University of York. DARE records cover topics such as diagnosis, prevention, rehabilitation, screening, and treatment.
Via EBSCO
Systematic Reviews are also searchable in MEDLINE:
- Ebsco MEDLINE: Select Advanced Search. Enter your search query. Click on the “Reviews - High Sensitivity” under the Clinical Queries limiter.
- PubMed: Click on “Clinical Queries” on the left side of the screen; select “Find Systematic Reviews” and enter your search query.
Authors of critically-appraised topics evaluate and synthesize multiple research studies.
National Guideline Clearinghouse
A comprehensive database of evidence-based clinical practice guidelines and related documents produced by the Agency for Health Care Research and Quality, in partnership with the American Medical Association and the American Association of Health Plans. Updated weekly.
Note: Guideline evidence varies from expert opinion to high levels of evidence.
Critically-Appraised Individual Articles
Authors of critically-appraised individual articles evaluate and synopsize individual research studies.
Bandolier is an independent journal about evidence-based healthcare published in the UK. It includes “information about evidence of effectiveness (or lack of it), and put[s] the results forward as simple bullet points of those things that worked and those that did not: a bandolier with bullets. Information comes from systematic reviews, meta-analyses, randomised trials, and from high quality observational studies.”
Quality articles from over 110 clinical journals are selected by research staff, and then rated for clinical relevance and interest by an international group of physicians. Includes a searchable database of the best evidence from the medical literature and an email alerting system. From BMJ Publishing Group and McMaster University's Health Information Research Unit.
Evidence is not always available via filtered resources. Searching the primary literature may be required. It is possible to use specific search strategies in MEDLINE and other databases to achieve the highest possible level of evidence.
To limit your PubMed search to the best evidence-producing studies: Click on "clinical queries" (on the left side of the screen). This specialized search is intended for clinicians and has built-in search "filters." Four study categories--therapy, diagnosis, etiology, prognosis--are provided, and you may indicate whether you wish your search to be more sensitive (i.e., include most relevant articles but probably including some less relevant ones) or more specific (i.e., including mostly relevant articles but probably omit a few).
Cumulative Index to Nursing and Allied Health Literature from EBSCO
To limit your CINAHL search to the best evidence-producing studies: Under the ‘Limit Your Results’ section, Select from the options listed under ‘Clinical Queries’ or limit to ‘Research’ or other ‘publication’ types (i.e., systematic review).
Background Information/Expert Opinion
Note: Evidence in these resources may vary from expert opinion to high levels of evidence.
Physician authors and editors contribute to the eMedicine Clinical Knowledge Base, which contains articles on 7,000 diseases and disorders. The evidence-based content provides the latest practice guidelines in 62 medical specialties. eMedicine's professional content undergoes multiple levels of physician peer review.
Select from one of our collections of full-text electronic books., including ebrary, netlibrary, Salem Health, and Gale Virtual Reference Library
Evidence-Based Medicine Information Sites
Centre for Evidence-Based Medicine (Oxford University)
The Centre promotes evidence-based health care and provide support and resources to anyone who wants to make use of them. Includes the EBM Toolbox, an assortment of materials which are very useful for practitioners of EBM, and EBM Teaching Materials, including PowerPoint presentations.
Centre for Evidence-Based Medicine (Toronto)
Includes many resources for practicing and teaching EBM.
Introduction to Evidence-Based Practice
EBP Tutorial: Module 1: Intro to EBP
Evidence-Based Medicine Tutorials
Introduction to Evidence-Based Medicine
From Duke University Medical Center Library and University of North Carolina at Chapel Hill Health Sciences Library.
SUNY Health Sciences Evidence-Based Medicine Course
Evidence-Based Medicine Resources for PDA
Evidence-Based Medicine Resources for the PDA
A list of resources from the Dartmouth Biomedical Libraries.
Local Resources (e.g., Class Handouts, Tip Sheets)
EBP experts use PICO (Patient, Intervention, Comparison, Outcome) to develop answerable patient-centered questions.
Most people search by using very simple queries ... one or two words at most. By importing terms from your PICO question to your literature search, you can more effectively hone in on clinical research pertinent to your patient's problem.
Using PICO, as a method for building your search, try this approach:
Searching is iterative ... we find that a little trial and error with these search strategies can pay off with access to clinical information that can help you more effectively take care of your patients.
Forming Focused Questions with PICO (University of N Carolina Health Sciences Libraries)